Web作用，转录因子（transcription factor，TF）在造血分化过程中 发挥了核心调节作用，在多系分化方向关键点控制HSPC分 化命运。 WebGATA1 is considered as the "master" transcription factor in erythropoiesis. It regulates at the transcriptional level all aspects of erythroid maturation and function, as …

Activation of γ-globin gene expression by GATA1 and NF-Y in ... - Nature

WebGATA transcription factors comprise a family of zinc finger proteins that bind the consensus DNA sequence (T/A)GATA (A/G). There are six known members of the … GATA1 was first described as a transcription factor that activates the hemoglobin B gene in the red blood cell precursors of chickens. Subsequent studies in mice and isolated human cells found that GATA1 stimulates the expression of genes that promote the maturation of precursor cells (e.g. erythroblasts) to … See more GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and … See more The human GATA1 gene is located on the short (i.e. "p") arm of the X chromosome at position 11.23. It is 7.74 kilobases in length, consists of 6 exons, and codes for a full-length protein, … See more GATA1 gene mutations are associated with the development of various genetic disorders which may be familial (i.e. inherited) or newly acquired. In consequence of its … See more • Ohneda K, Yamamoto M (2003). "Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage". Acta Haematologica. … See more In both GATA1 and GATA1-S, C-ZnF (i.e. C-terminus zinc finger) binds to DNA-specific nucleic acid sequences sites viz., (T/A(GATA)A/G), … See more Myelofibrosis is a rare hematological malignancy characterized by progressive fibrosis of the bone marrow, extramedullary hematopoiesis (i.e. formation of blood cells outside of their normal site in the bone marrow), variable reductions in the levels of circulating blood … See more • Genecards • GeneReviews/NCBI/NIH/UW entry on GATA1-Related X-Linked Cytopenia See more scratch stickman animator

GATA-1 and NF-Y cooperate to mediate erythroid-specific …

WebOct 22, 2024 · GATA transcription factors are evolutionarily conserved among animals, plants and fungi. Vertebrates possess six paralogs, classified into two subfamilies based on their spatial and temporal expression patterns (Fig. 1A).Although originally divided as hematopoietic (GATA1/2/3) and cardiac (GATA4/5/6) GATA factors, their function and … WebJun 14, 2024 · The GATA1 gene encodes a zinc finger DNA-binding transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. The … WebHuman Molecular Genetics, 2002, Vol. 11, No. 2 149 Direct binding of the GATA1 mutants to DNA, studied as previously described by Freson et al. (15), was not disturbed (Fig. … scratch stick war game