Doxofylline is not just another theophylline

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August undefined, 2024

WebFeb 1, 2001 · In spontaneously beating right atria, doxofylline slightly increased the atrial rate, but only at 0.3 mM, while theophylline induced a concentrationdependent positive chronotropic effect that... WebDec 1, 2024 · Doxofylline and theophylline did not have overlapping effects on human monocytes. While sharing some common characteristics, they differed significantly in their selectivity. Theophylline affected LPS- above PMA-induced cellular responsivity, while doxofylline behaved in the opposite manner.

Doxofylline - Wikipedia

WebAfter intubation, the rats in group D were immediately given an intravenous injection of 50 mg/kg of doxofylline (dissolved in 0.2 mL of NS), following Rao et al, 7 while the rats in groups C and N were immediately given an intravenous injection of an equal volume of NS. The rats in group M were not given an intravenous injection. WebDec 1, 2024 · It is now clear that doxofylline also possesses a distinct pharmacological profile from theophylline (no significant effect on any of the known phosphodiesterase … hub international brantford

Doxofylline and theophylline: a comparative clinical study.

WebDec 5, 2024 · Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of … WebDec 5, 2024 · It is now clear that doxofylline also possesses a distinct pharmacological profile from theophylline (no significant effect on any of the known phosphodiesterase … WebNational Center for Biotechnology Information hub international boise id

Inflammatory response in ventilated rats with COPD COPD

Doxofylline is not just another theophylline! COPD

Doxofylline (also known as doxophylline) is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma and COPD. Like theophylline, it is a xanthine derivative. WebAug 3, 2024 · Doxofylline was as effective as theophylline in improving FEV1, and a trend of superiority (P = 0.058) was detected for doxofylline over theophylline with respect to the reduction in the... hogy in englishWebDoxophylline differs from theophylline in that it contains a methylene 1,3-dioxolane group at position 7 ( Figure 1), resulting in a different profile. 8 At the pharmacological level, it has been... hub international breach

"WebSep 1, 2009 · Unlike theophylline, doxofylline does not antagonize calcium channels, nor does it interfere with the influx of calcium into the cells, which probably reduces the cardiac side effects.... " - Doxofylline is not just another theophylline

Doxofylline is not just another theophylline

WebDec 1, 2024 · Conclusions: Doxofylline is an effective and safe methylxanthine for the treatment of asthma, with an efficacy/safety profile greater than that of theophylline. Trial registration:... WebDoxofylline is a newer generation xanthine with both bronchodilating and anti-inflammatory activities and for this reason it has been called "novofylline". It differs substantially from …

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WebJan 20, 2014 · Theophylline, aminophylline, doxofylline and diprophylline are used in the therapy of bronchial asthma and chronic obstructive pulmonary diseases (COPD) [8, [10] [11] [12] [13]. In particular,... WebJun 22, 2024 · Doxofylline is metabolized as a theophylline derivative by the liver, and eliminated by urinary excretion within 12 h after the administration. In contrast to …

WebIn contrast with other xanthine derivatives, doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. ... Matera MG, … WebIt has also been shown to have superior gastric tolerability as compared to theophylline, and does not increase myocardial oxygen demand, hypertension, or affect cardiovascular side-effects. It may become more effective and more usable than theophylline for bronchial asthma or COPD.

WebMay 1, 2002 · Experimental studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra-respiratory effects than theophylline. This trial was designed to compare... WebJun 6, 2024 · Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and displays a better safety profile than theophylline.

WebDec 1, 2012 · Doxofylline has no advantage over theophylline in terms of either efficacy or safety on the doses commonly used in current clinical practice in patients of COPD. Theophylline has been used in the treatment of COPD for decades. Doxofylline a new theophylline congener has been claimed to have better safety profile.

WebDec 1, 2024 · Unlike theophylline, doxofylline does not require blood testing. It can be administered together with or as an alternative to a series of other drugs considered in additional therapy. hogy indicator tapeWebDec 15, 2012 · Theophylline has an antagonistic action on the adenosine A1, A2a and A2b receptors, which is responsible for its cardiac and central nervous system stimulatory … hogy internWebDoxofylline is not just another theophylline! Matera MG, Page C, Cazzola M. International Journal of Chronic Obstructive Pulmonary Disease 2024, 12:3487-3493 Published Date: 5 December 2024. Original Research. The impact of dual bronchodilation on cardiovascular serious adverse events and mortality in COPD: a quantitative synthesis. hub international boston maWebDec 5, 2024 · Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of … hogy inshore back pack youtubeWebDoxofylline was significantly (p<0.001) safer than both aminophylline and theophylline, whereas no difference resulted versus bamiphylline. No significant differences were detected with regard to the risk of adverse events across aminophylline, bamiphylline and theophylline ( figure 1b ). hub international bothell waWebMay 1, 2016 · DOI: 10.1016/j.arbres.2015.02.021 Corpus ID: 1156341; Chronic Use of Theophylline and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-analysis. @article{Horita2016ChronicUO, title={Chronic Use of Theophylline and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-analysis.}, author={Nobuyuki Horita and Naoki … hub international bozemanWebApr 14, 2024 · Doxofylline is a bronchodilator that helps relax the smooth muscles of the airways in your lungs [ 12 ]. Asthma and other obstructive lung diseases are treated with it to either cure or prevent the problems associated with breathing. It is used to treat lung problem symptoms such wheezing, tightness in the chest, and shortness of breath [ 13 ]. hogy medical asia pacific