WebFeb 21, 2006 · Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. … WebMar 1, 2024 · EME1 → Crossover junction endonuclease EME1 [ EC 3.1.22.- ] Protein also known as : MMS4 homolog (hMMS4) . Gene name : EME1 Family name : …
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WebAug 19, 2024 · The endonuclease activity of the MutLγ complex has been implicated in the resolution of crossovers 5, 6, 7, 8, 9, 10, but the mechanisms that activate and direct strand-specific cleavage remain... WebMar 1, 2003 · 1.10.150.670 Crossover junction endonuclease EME1, DNA-binding domain 1 hit 3.40.1620.30 ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 1 1 hit 4.10.800.30 ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 2 1 hit
WebApr 11, 2024 · There are two major pathways for meiotic crossing-over. One pathway requires many proteins, including the ZMM group (ZYP1-4, MSH4-5, MER3) and the MutL homolog 1 (MLH1)/MLH3 complex [ 29, 30 ]. COs produced by this pathway, named class I COs, are subject to interference. WebOrthologous to human EME1 (essential meiotic structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Apr 2024] Other designations crossover junction endonuclease EME1, essential meiotic endonuclease 1 homolog 1 GeneRIFs: Gene References Into Functions
WebDescription: Mus musculus MUS81 structure-specific endonuclease subunit (Mus81), transcript variant 1, mRNA. (from RefSeq NM_027877) Gencode Transcript: ENSMUST00000124334.7 ... DESCRIPTION: RecName: Full=Crossover junction endonuclease MUS81; EC=3.1.22.-; FUNCTION: ... Analysis of crossover junction endodeoxyribonucleases from bacteriophages (T7 endonuclease I), bacteria (RuvC), fungi (GEN1) and humans (hMus81-Eme1) have revealed that the enzymes function in dimers, and part of the resolution reaction takes place in a partially dissociated enzyme-substrate … See more Crossover junction endodeoxyribonuclease, also known as Holliday junction resolvase, Holliday junction endonuclease, Holliday junction-cleaving endonuclease, Holliday junction-resolving … See more The Holliday junction is a structure that forms during genetic recombination, and links two double-stranded DNA molecules with a single-stranded crossover, which form during See more These enzymes are highly selective for branched DNA, although induced fit occurs in the enzyme-substrate (resolvase-Holloday Junction) complex formation. Much remains … See more • See more E. coli RuvC, a Crossover junction endodeoxyribonuclease, is a small protein of about 20 kD, and its active form is a dimer that requires and binds a magnesium ion [1]. RuvC is a 3 … See more After a 20-year search, in 2008, a human crossover junction endodeoxyribonuclease, GEN1, was finally identified . GEN1 … See more
WebThese patterns suggest that a crossover-isomer bias exists in these molecules and that the protected strands form the crossover between helices. Here, we examine the cleavage …
WebThis crossover structure formed is called Holiday junction. Holliday junction moves in lateral direction. During this process a DNA strand is progressively exchanged with a DNA strand of the other helix. This lateral migration of Holliday junction is … table covers that look like woodWebThe encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA … table cr 2bWebDec 20, 2005 · Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. table covers personalizedWebGene Ontology Term: crossover junction DNA endonuclease activity. Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover … table craft 42WebJan 20, 2004 · The heterodimeric enzyme Mus81–Eme1, a DNA structure-specific endonuclease of the XPF family 5., 6., 7., has been proposed to be a Holliday junction resolvase in fission yeast and human cells 8., 9..Three papers 10., 11., 12. have now reported compelling evidence that Mus81–Eme1 is responsible for the vast majority of … table craft fermobWebAug 25, 2024 · Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC123190788 crossover junction endonuclease … table covers partyWebMar 1, 2024 · Analysis of crossover junction endodeoxyribonucleases from bacteriophages (T7 endonuclease I), bacteria (RuvC), fungi (GEN1) and humans (hMus81-Eme1) have revealed that the enzymes function in dimers, and part of the resolution reaction takes place in a partially dissociated enzyme-substrate intermediate. table craft sauce cups and lids